Well pretty much yeah, if you disconnect the throttle body you will need to/should get throttle body calibration done..
And if you haven't cleaned the throttle body I would say start off by removing the plastic pipe from the airfilter box to the throttle body, check how clean the throttle body looks, open it and look inside, if it's rather dirty/oily I would say remove it and clean it out.
The slightest dirt can affect running.