yes it will need setting up again, as the compression will have increased but without the oil seepage the mixture will be less prone to detonation so it chould be anywhere.
as for running it i can't give you the answer and someone will disagree, my personal oppinon is they don't need meany miles at all if you build it righ so i often use the hard and fast approach to breack them in. ( unless it's a really old engine desing ) . as soon as it's running i think it should be driven, don't make it labour but keep the revs off for a bit, once it's warmed and done a few part throttel pulls to 3000 rpm i'll be giveing it full throttel between 2 & 3 k rpm then 2& 4 k rpm, then 2&5 k rpm. and letting it engine brake back down in between.
if you build the bottom end to tight that method can and will spin a shell, but as all the parts are produced to tight tolerances and it's possibel to measure them quite easly there should be no tight bearings so see no reason not to give them some load. tho i would leave the last 1500 - 2000 rpm allone till its done a few hundred miles