low comp pistons is how it should be done but most people never bother on the vr6, they mostly get away with it because it's not actualy makeing that much power per cylinder.
stock 16v makes 37.5 bhp per cyl. tuned NA 16v can do 50 bhp per cyl on std guts
225 bhp = 37.5 bhp per cyl no more stressed than a std 16v
300 bhp = 50 bhp per cyl. stock rods, bearings and pistons will hold that happily.
450 bhp = 75 bhp per cyl. you want to start thinking about shiney bits
600 bhp = 100bhp per cyl. even with shiney bits any more and it's not going to do reliable imo