Short answer - yes, to a degree.
I’ve had a good few cars remapped over the decades, both petrol and Diesel.
I didn’t remap for boy racer purposes either, just improved driveability in the mid-range, so didn’t go chasing big numbers.
The degree of extra wear will depend on how hard you drive the vehicle obviously, but even driven sensibly the nature of remapping will lead to at least a degree of extra wear.
The turbo boost will be increased from the get go so a little bit of extra pressure on the bearings plus the various valves that regulate the amount of boost going in to the engine is a given.
A sympathetic driving style and using the best oils will minimise any extra wear and ensuring the oil is up to temperature is essential if you’re going to be making the best of the extra performance.
The manual gearbox itself isn’t a weak point but the OEM clutches aren’t up to taking on extra load, even when new the manual clutches could be borderline on a standard engine.
If keeping a tuned car longer term then extra oil changes would be a wise investment.