jbl's arent free air, so will need either an enclosed or ported box.... dependant on wat sort of music u listen to, ports in boxes can change the sound the sub produces, creating a shorter crisper bass note, rather than a longer one.
and personally, id go for either 2x12's, or the single 15" sub, wouldnt mix and fit them both.... no real need, they would have different ranges, and produce different sounds, might sound too 'hetic' if u kno wat i mean... im not expert however, so this is mostly personal opinion and stuff ive picked up over time.
ive got a single 12" JL audio w0 sub, hooked upto a 500watt amp, and it has some serious kick to it.... so id get rid of the 15, and just go with a single 12, or possibly 2x12" ones instead.
it would also make creating an install easier as both side would need to be the same, rather than having to create more internal space for the 15" than the 12" speaker.