I like a gadget
Although I can't really think of anything clever I've setup on my Mk7.5.
Maybe the only things are:
1) Setting left mirror dip (v useful)
2) Making sure manoveur braking is turned on (saved me from a couple of prangs)
3) Setting ACC distance to the closest one (otherwise people decide to get into the gap that you leave... which makes your car brake and open the gap up... repeat ad infinitum)
4) In the drive mode profile, setup up individual mode to set engine noise to eco (which mainly turns off the soundaktor) and then whatever other settings you like. Use individual as your main daily profile.
5) Play around with and find your happy place in the AID views setup.
6) Turn up the front assist (collision detection) by one notch from standard. You'll get more alerts about pending doom but I'd sooner that than crash.
Add to that, learn how to update the satnav maps.